Longevity MUST Address the 4 Horsemen….the Top Killers In America Today….

The 4,000-Week Reality

The average American lives: 4,000 weeks, or roughly 77 years. That is startlingly brief. What's more concerning is that while Americans are aging as a population, we're not living longer. Since 2013, U.S. life expectancy has declined. COVID-19 accelerated this trend, and unlike other developed nations where life expectancy has rebounded, ours has not. We're dying younger while spending more years in poor health. This growing burden of morbidity demands a solution.

The Centenarian Paradox

Today's centenarians didn't biohack their way to 100—they won the genetic lottery. Many reached that milestone despite poor habits, purely through biological luck. The odds? Roughly 1 in 5,000, possibly lower now.

Redefining the Goal

For my clients, the objective isn't simply living longer—it's compressing illness and disability into the final months of life while dramatically extending healthspan. The traditional trajectory shows health declining steadily from birth. Our goal is different: maintain optimal function as long as possible, then experience a rapid decline only at life's end.

The Paradigm Shift

Current medical practice focuses on managing chronic disease—helping people live longer with illness. This approach won't get anyone to 100. Instead, we must prevent or significantly delay chronic disease onset. Rather than developing life-threatening conditions in our 50s and 60s, we should push them into our 80s and 90s—or avoid them entirely.

The Four Horsemen

Four disease categories account for over 80% of deaths among non-smokers:

  1. ASCVD (atherosclerotic cardiovascular disease—heart attacks and strokes)

  2. Cancer

  3. Neurodegenerative disease

  4. Metabolic dysfunction (diabetes, fatty liver disease, insulin resistance)

These are largely preventable with the right interventions.

The Foundation

Preventing ASCVD—still America's leading killer by a wide margin—requires addressing these fundamentals:

  • Exercise

  • Nutrition

  • Sleep

  • Lipid management

  • Inflammation control

  • Glycemic control

ASCVD also contributes to neurodegeneration, particularly vascular dementia. The good news? What protects the heart protects the brain, and vice versa.

The Bottom Line

This isn't rocket science. By focusing on these core interventions, we can help clients live not just longer lives, but functional ones. That's the true measure of success. We measure them, we correct where things are going wrong. And then we monitor. We become the watchman.

How We Use Our Advanced Testing Protocols:

Get the Testing

  • What actually drives ASCVD:

    • Atherogenic lipoprotein burden

    • Endothelial dysfunction

    • Chronic inflammation

    • Insulin resistance

    • Accelerated biological aging

    How Body MAX Harmonics tests it

    1. SiPhox Health – Ultimate Health Panel

    Primary role: Direct cardiovascular risk biology

    Measures:

    • ApoB / LDL-C / Non-HDL cholesterol

    • Triglycerides

    • hs-CRP (vascular inflammation)

    • HbA1c, fasting glucose (metabolic contribution)

    • Liver enzymes (NAFLD link to ASCVD)

    Identifies plaque-driving particle burden and inflammatory risk

    2. Theriome Aristotle

    Primary role: Epigenetic cardiovascular risk

    Assesses:

    • Epigenetic expression of cardiovascular disease pathways

    • Inflammatory and immune aging signatures

    • Stress-response and repair capacity

    Detects “hidden” ASCVD risk even with normal cholesterol

    3. DNA 360

    Primary role: Genetic predisposition

    Assesses:

    • Lipid metabolism genes (ApoB, LDL handling)

    • Inflammation pathways

    • Thrombosis risk

    • Blood pressure regulation

    Explains WHY risk exists, not just that it exists

    4. GlycanAge

    Primary role: Cardiovascular aging velocity

    Measures:

    • Immune system glycan patterns

    • Chronic inflammation burden

    • Biological age vs chronological age

    ASCVD is an aging disease — this shows how fast the clock is ticking

    ASCVD = Particle burden + inflammation + aging + genetics

  • What actually drives cancer risk

    • Immune surveillance failure

    • Epigenetic dysregulation

    • Chronic inflammation

    • Impaired detoxification

    • Accelerated biological aging

    How Body MAX Harmonics tests it

    1. Theriome Aristotle

    Primary role: Cancer epigenetic signaling

    Detects:

    • Oncogenic pathway activation

    • Tumor suppressor gene silencing

    • Inflammatory cancer-promoting environments

    • Immune exhaustion signatures

    Cancer risk often appears epigenetically before imaging or labs

    2. DNA 360

    Primary role: Genetic susceptibility

    Assesses:

    • DNA repair pathways

    • Detoxification capacity

    • Estrogen metabolism

    • Oxidative stress handling

    • Familial cancer risk genes

    Identifies vulnerability, not destiny

    3.MeScreen

    Primary role: Immune surveillance & metabolic terrain

    Assesses:

    • Immune signaling balance

    • Inflammatory tone

    • Metabolic stress markers

    Cancer thrives when immunity and metabolism are dysregulated

    4.GlycanAge

    Primary role: Inflammaging & cancer risk

    Measures:

    • Chronic immune activation

    • Pro-inflammatory glycan patterns linked to malignancy risks

    Cancer risk rises sharply with immune aging

    Cancer = Epigenetic signals + immune failure + inflammation + aging‍

  • What actually drives Neurodegeneration

    • Insulin resistance of the brain

    • Chronic inflammation

    • Vascular compromise

    • Immune dysregulation

    • Accelerated brain aging

    How Body MAX Harmonics tests it

    1. SiPhox Ultimate Health Panel

    Primary role: Metabolic & vascular contributors

    Measures:

    • HbA1c & glucose (Type 3 diabetes risk)

    • Lipids (vascular dementia risk)

    • Inflammatory markers

    What’s bad for the heart is bad for the brain

    2. Theriome Aristotle

    Primary role: Epigenetic brain risk

    Assesses:

    • Neuroinflammatory pathways

    • Neuronal repair and resilience

    • Stress response signaling

    • Cognitive decline signatures

    Detects brain aging before symptoms appear

    3. DNA 360

    Primary role: Genetic risk mapping

    Assesses:

    • Neurodegeneration susceptibility genes

    • Detox pathways affecting brain health

    • Inflammation and mitochondrial genes

    Explains individual vulnerability

    4. GlycanAge

    Primary role: Brain-aging proxy

    Measures:

    • Systemic inflammation linked to dementia risk

    • Immune aging patterns correlated with cognitive decline

    Neurodegeneration is immune-aging driven

    Neurodegeneration = Metabolic + vascular + inflammatory + epigenetic aging

  • What actually drives metabolic dysfunction

    • Insulin resistance

    • Mitochondrial failure

    • Chronic inflammation

    • Hormonal dysregulation

    • Accelerated biological aging

    How Body MAX Harmonics tests it

    1.SiPhox Ultimate Health Panel

    Primary role: Direct metabolic health

    Measures:

    • Glucose

    • HbA1c

    • Lipids

    • Liver enzymes

    • Insulin resistance markers

    Core metabolic dysfunction detection

    2.MeScreen

    Primary role: Metabolic signaling & immune balance

    Assesses:

    • Stress biology

    • Inflammatory tone

    • Metabolic resilience

    Shows why diet/exercise may not be working

    3.DNA 360

    Primary role: Genetic metabolic constraints

    Assesses:

    • Insulin signaling genes

    • Fat metabolism

    • Appetite regulation

    • Mitochondrial efficiency

    Explains weight resistance and metabolic stagnation

    4.GlycanAge

    Primary role: Metabolic aging

    Measures:

    • Inflammaging

    • Metabolic age vs chronological age

    Metabolic disease is accelerated aging in disguise

    Metabolic Dysfunction = Insulin resistance + inflammation + genetics + aging

Our Process

Plan with Purpose

Together, we outline a path forward that’s realistic, strategic, and tailored to your specific needs. We pick the tests right for your situation, and then GO DEEP.

Collaborate Openly

You’re part of the process. We keep communication open and decisions shared—no black boxes or surprises.. The testing drives EVERY DECISION.

Design the Protocol

Now we know the targets, and we know YOU. We can now design EXACTLY what to do next and how to measure progress. WE GET BUSY!

Remeasure and Adapt

By now, we are progressing. We are crushing through the 4,000 weeks into a life lived healthy, long and vital. But we continue to keep WATCH.